• 2022-09
  • 2022-08
  • 2022-07
  • 2022-06
  • 2022-05
  • 2022-04
  • 2022-02
  • 2021-03
  • 2020-08
  • 2020-07
  • 2020-03
  • 2019-11
  • 2019-10
  • 2019-09
  • 2019-08
  • 2019-07
  • br facilitates breast cancer metastasis through its


    facilitates breast cancer metastasis through its actions on immune cells, Nat.
    [16] F. Maione, S. Oliaro-Bosso, C. Meda, et al., The cholesterol biosynthesis enzyme oxidosqualene cyclase is a new target to impair tumour angiogenesis and metastasis dissemination, Sci. Rep. 5 (2015) 9054. [17] M.G. Caruso, A.R. Osella, M. Notarnicola, et al., Prognostic value of low density lipoprotein receptor Thapsigargin in colorectal carcinoma, Oncol. Rep. 5 (1998) 927–930.
    [18] M.G. Caruso, M. Notarnicola, M. Santillo, et al., Enhanced 3-hydroxy-3-methyl-glutaryl coenzyme a reductase activity in human colorectal cancer not expressing low density lipoprotein receptor, Anticancer Res. 19 (1999) 451–454.
    [19] E. Bengtsson, P. Nerjovaj, S. Wangefjord, et al., HMG-CoA reductase expression in primary colorectal cancer correlates with favourable clinicopathological char-acteristics and an improved clinical outcome, Diagn. Pathol. 9 (2014) 78. [20] C. Aguirre-Portolés, J. Feliu, G. Reglero, et al., ABCA1 overexpression worsens colorectal cancer prognosis by facilitating tumour growth and caveolin-1-depen-dent invasiveness, and these effects can be ameliorated using the BET inhibitor apabetalone, Mol. Oncol. (2018) 1735–1752.
    [22] S. Borgquist, S. Djerbi, F. Pontén, et al., HMG-CoA reductase expression in breast cancer is associated with a less aggressive phenotype and influenced by anthro-pometric factors, Int. J. Cancer 123 (2008) 1146–1153. [23] D.J. Brennan, J. Brändstedt, E. Rexhepaj, et al., Tumour-specific HMG-CoAR is an independent predictor of recurrence free survival in epithelial ovarian cancer, BMC Cancer 10 (2010) 125.
    [37] Y. Zheng, Y. Liu, H. Jin, et al., Scavenger receptor B1 is a potential biomarker of human nasopharyngeal carcinoma and its growth is inhibited by HDL-mimetic nanoparticles, Theranostics. 3 (2013) 477–486.
    [43] X. He, Z. Chen, M. Jia, et al., Downregulated E-cadherin expression indicates worse prognosis in Asian patients with colorectal cancer: evidence from meta-analysis, in:  BBA - Molecular and Cell Biology of Lipids 1864 (2019) 1314–1327
    Contents lists available at ScienceDirect
    Nuclear Medicine and Biology
    Clinical scale synthesis of intrinsically radiolabeled and cyclic RGD peptide functionalized 198Au nanoparticles for targeted cancer therapy
    Rubel Chakravarty a,d, , Sudipta Chakraborty a,d, Apurav Guleria b, Chandan Kumar a, Amit Kunwar b, K.V. Vimalnath Nair a, Haladhar Dev Sarma c, Ashutosh Dash a,d
    a Radiopharmaceuticals Division, Bhabha Atomic Research Centre, Trombay, Mumbai 400 085, India
    b Radiation and Photochemistry Division, Bhabha Atomic Research Centre, Trombay, Mumbai 400 085, India
    c Radiation Biology and Health Sciences Division, Bhabha Atomic Research Centre, Trombay, Mumbai 400 085, India
    d Homi Bhabha National Institute, Anushaktinagar, Mumbai 400 094, India
    Article history:
    Keywords: 198Au
    Cancer therapy
    Intrinsically radiolabeled nanoparticles
    Introduction: The emerging concept of intrinsically radiolabeled nanoparticles has the potential to transform the preclinical and clinical studies by improving the in vivo stability and demonstrating minimal alteration in the in-herent pharmacokinetics of the nanoparticles. In this paper, a simple and efficient single-step method for clinical scale synthesis of intrinsically radiolabeled 198Au nanoparticles conjugated with cyclic arginine−glycine−aspar-rtate peptide (198AuNP-RGD) is reported for potential use in targeted cancer therapy.
    Methods: Large radioactive doses (N37 GBq) of 198AuNP-RGD were synthesized by reaction of 198Au-HAuCl4 with cyclic RGD peptide. The synthesized nanoparticles were characterized by various analytical techniques. In vitro cell binding studies were carried out in B16F10 (murine melanoma) cell line. Biodistribution studies were carried out in melanoma tumor bearing C57BL/6 mice to demonstrate the tumor targeting ability of 198AuNP-RGD. The therapeutic efficacy of 198AuNP-RGD was evaluated by carrying out systematic tumor regression studies in mel-anoma tumor bearing mice after intravenous administration of the radioactive doses.