• br Materials and methods br Results br Discussion

  2019-07-08

  

  Materials and methods Results Discussion In our current research, we revealed that lncRNA CYTOR Pam3CSK4 was remarkably upregulated in cardiac and cardiomyocyte hypertrophy. CYTOR knockdown could aggravate AB-induced cardiac hypertrophy or Ang II-induced cardiomyocyte hypertrophy in vitro

• In the present study by using

  2019-07-08

  

  In the present study, by using Nrf2 knockout (Nrf2 KO) mice and IL-6 knockout (IL-6 KO) mice, we show a previously unidentified role for Nrf2 in agonist-induced activation of IL-6/STAT3 signaling pathway and evaluated its effect on IL-6 mediated myocardial inflammation. Our results support that Nrf2

• In patients with myocardial infarction MI myocardial chymase

  2019-07-08

  

  In patients with myocardial infarction (MI), myocardial chymase activity increased at 14–21 day post-MI [13], suggesting a role of chymase in a later phase post-MI myocardial remodeling. Chymase functions in CVD have undergone thorough testing using chymase inhibitors and chymase-deficient mice. In

• While all branches of the proteostasis network

  2019-07-06

  

  While all branches of the proteostasis network are affected by age, a temporal decline in autophagy is believed to be a major contributor to time-dependent changes in cardiac function [[122], [123], [124]]. Autophagy plays an integral role in removing dysfunctional organelles and protein Ezatiostat

• br Mechanism of MeHg induced neurotoxicity br PTMs

  2019-07-05

  

  Mechanism of MeHg-induced neurotoxicity PTMs - a mechanism to diversify protein functions The function, structure and stability of proteins in 158021-47-7 are frequently modulated by chemical modifications introduced after translation from RNA. PTMs are important steps in the biosynthesis of

• Introduction Since the th century nitrates and

  2019-07-05

  

  Introduction Since the 19th century, nitrates and nitrites were known to be vasoactive, being applied in medicine however the mechanisms activated by such compounds were unknown [1]. At the beginning of the 80's of the last century the effect of endothelial cells in vasodilatation was demonstrated

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